通过GRAPE-LM,RNA吸收体的单一循环进化
Jun Zhang1,2, Ju Zhang3,4, Shaoxuan Tang5,6
1School of Artificial Intelligence, Shenzhen University, Shenzhen, China. junzhang@szu.edu.cn.
Nature biotechnology
|February 6, 2026
概括
研究人员开发了GRAPE-LM,这是用于快速演变的RNA体的AI框架. 这种方法显著优于传统技术,仅在一轮选中就能取得卓越的结果.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 人工智能的人工智能
背景情况:
- 定向进化对生物分子发展至关重要,但RNA进化落后于蛋白质进化.
- 传统的RNA胺体发现涉及艰苦的,多轮选过程.
- 语言模型的进步加速了蛋白质的进化,突出了对类似RNA工具的需求.
研究的目的:
- 介绍GRAPE-LM,这是一个新型的生成AI框架,用于一轮RNA体进化.
- 为了证明GRAPE-LM在快速发现高亲和度RNA体的能力.
- 为了克服传统的多轮选方法在aptamer选择的局限性.
主要方法:
- GRAPE-LM集成了基于变压器的条件自编码器与核酸语言模型.
- 该框架利用来自细胞内环境的基于CRISPR-Cas的aptamer查数据作为指导.
- 该系统的设计是为了有效的,一轮进化RNA的aptamers.
主要成果:
- GRAPE-LM成功生成了针对三个不同的点的RNA吸收体:CD3ε,SARS-CoV-2 RBD和c-Myc.
- 人工智能生成的aptamers表现优于通过多轮人类选择和优化获得的aptamers.
- 该框架甚至在有限的查数据 (单一轮) 中也表现出有效性.
结论:
- GRAPE-LM 提供了RNA 体进化的显著进步,使得快速,一轮发现.
- 人工智能框架为传统的,耗时的aptamer选择方法提供了强大的替代方案.
- GRAPE-LM在具有挑战性的目标 (如细胞内无序蛋白质) 的成功扩大了其适用性.
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