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延迟带紧 (DCC) 在1分钟与3分钟的早产新生儿 - 一个开放的标签随机化,受控试验
Ashadur Zamal1, Rajib Losan Bora2, Sambhunath Bandyopadhyay3
1Department of Neonatology, IPGME&R and SSKM Hospital, Kolkata, West Bengal, India.
European journal of pediatrics
|February 6, 2026
概括
延迟带紧3分钟显著改善了早产新生儿的血压和血红素水平. 这3分钟的延迟带紧 (DCC) 为早产婴儿提供了一种有益的胎盘输血策略.
科学领域:
- 新生儿医学 新生儿医学
- 儿科 儿科 儿科
- 产科 产科 产科 产科 产科
背景情况:
- 推迟带紧 (DCC) 建议适用于充满活力的新生儿,但最佳时间尚不清楚.
- 关于特别针对早产婴儿的DCC有效持续时间的研究有限.
- 目前的指导方针在DCC的确切持续时间方面缺乏统一性.
研究的目的:
- 为了比较1分钟与3分钟的DCC对早产新生儿血液学和血液动力学参数的影响.
- 评估DCC持续时间对静脉血红素,血压和新生儿疾病的影响.
- 为了确定30-36岁的早产婴儿中DCC的最佳时间,怀孕6/7周.
主要方法:
- 一个分层的随机受控试验,涉及304名早产新生儿 (30-36 6/7周怀孕).
- 参与者被分配到1分钟的DCC或3分钟的DCC,比例为1:1.
- 主要结局:静脉血红素在48小时;次要结局:过渡性血压,血红素和费里丁在6周,新生儿发病率.
主要成果:
- 3分钟的DCC组在48小时内显示出明显更高的静脉血红素平均值 (43.18%与41.02%对比).
- 在3分钟DCC组中,在过渡期内观察到更高的平均血压和12小时和6周的平均血红素值升高.
- 两组之间在新生儿发病率 (如光疗或症状性多细胞血症) 上没有发现显著差异.
结论:
- 延迟带紧3分钟会提高血压,并在早产新生儿中增加静脉血红素.
- 三分钟DCC似乎是一个可行的和有效的胎盘输血技术为早产婴儿.
- 需要进一步的大规模多中心研究来证实3分钟DCC的有效性和安全性.
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