来自Carthamus tinctorius L.的总黄类药物通过Hippo/YAP途径抑制肝纤维化进展
Xiaomei Bao1, Xiaolu Zhao2,3, Haisheng Wang2
1College of Pharmacy, Inner Mongolia Medical University, Hohhot, China.
Journal of natural medicines
|February 6, 2026
概括
来自Carthamus tinctorius L. (TFCTL) 的总黄素在治疗肝纤维化方面显示出显著的潜力. 通过准Hippo/YAP通路,TFCTL抑制了肝星细胞的激活和增殖.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 自然产品 化学 化学
背景情况:
- 肝纤维化是全球主要的健康问题.
- 红杉 (Carthamus tinctorius L.) 是一种传统的草药,对肝脏疾病具有潜在的治疗特性.
- 在Carthamus tinctorius L.中丰富的黄类化合物具有多种药理学活性.
研究的目的:
- 为了研究来自Carthamus tinctorius L. (TFCTL) 的总黄对肝纤维化的抗纤维作用.
- 阐明TFCTL对肝星细胞 (HSC) 和Hippo/YAP通路的作用的潜在机制.
主要方法:
- 使用LC-MS/MS对TFCTL组合的表征.
- 建立用于肝纤维化的小鼠模型和用于HSC激活的体外模型 (HSC-T6细胞).
- 使用CCK-8,西式涂抹,RT-qPCR和免疫光检测对细胞效应的评估.
主要成果:
- TFCTL对HSC-T6细胞激活和增殖表现出抑制作用.
- 通过上调MST1和LATS1的调节,TFCTL促进YAP的酸化和降解,从而抑制Hippo通路的基因.
- 在小鼠中,TFCTL治疗显著改善了肝纤维化病理,主要通过Hippo/YAP途径进行介导.
结论:
- TFCTL表现出强大的抗纤维性质.
- 河马/YAP通路是TFCTL发挥治疗作用的关键机制.
- TFCTL代表了开发新型肝纤维化治疗的有前途的天然化合物.
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