评估TST/C-TST组合用于潜伏结核病感染查:与TST/IGRA相比,诊断性能和成本效益
Xin Zhang1,2,3, Lirong Mao1, Renkun Nie4
1Tuberculosis Control Team, Senior Department of Tuberculosis, The Eighth Medical Center of PLA General Hospital, Haidian Distinct, Beijing, 100091, China.
结合性结核素皮肤测试 (TST) 和复合性Mycobacterium结核病 (MTB) 融合蛋白皮肤测试 (C-TST) 显示,与传统的干扰素玛释放试验 (IGRA) 相比,潜伏结核感染 (LTBI) 查的准确性和成本效益有所提高. 这种新的策略为LTBI检测提供了一个有希望的替代方案.
科学领域:
- 传染病流行病学 传染病流行病学
- 诊断测试评价 诊断测试评价
- 公共卫生查 公共卫生查
背景情况:
- 针对潜伏结核感染 (LTBI) 的干扰素释量测试 (IGRA) 是复杂的,需要专门的设备.
- 重组性Mycobacterium结核病 (MTB) 融合蛋白皮肤测试 (C-TST) 使用与IGRAs相同的抗原.
- 评估C-TST的成本效益和与传统的结核素皮肤测试 (TST) 一致性对于潜在的LTBI查替代至关重要.
研究的目的:
- 将TST/C-TST查策略的诊断效率和成本效益与LTBI的传统TST/IGRAs策略进行比较.
- 评估用于LTBI查的联合TST和C-TST方法的潜力.
主要方法:
- 一组1412名18-40岁的男性接受了TST,C-TST和IGRA测试.
- 评估了TST,C-TST和IGRA (QFT-GIT) 的敏感性,特异性和可靠性.
- 一个混合决策树和马尔科夫模型评估了20年来五种查策略的成本和健康结果.
主要成果:
- 与TST/IGRA相比,TST/C-TST组合显示出更高的诊断效率 (AUC 0.821) 和成本效益.
- 个体测试的灵敏度为:TST (92.7%),C-TST (52.9%),IGRA (58.8%). 测试结果显示,每项测试的灵敏度均为:TST (92.7%),C-TST (52.9%),IGRA (58.8%). 具体的特点是:TST (56.0%),C-TST (83.6%),IGRA (83.6%). 这些特点包括:
- C-TST和IGRA显示出高一致性 (Kappa=0.869),但结合TST/C-TST策略被证明是最有效的.
结论:
- 综合的TST和C-TST查策略为LTBI检测提供了有希望的有效性和经济效益.
- 这种新的方法可能比传统的TST/IGRAs方法具有优势.
- 该TST/C-TST战略平衡了LTBI查的准确性和成本效益.
更多相关视频
09:23Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
Published on: June 30, 2019
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
相关概念视频
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Heart Failure IV: Classification and Diagnostic Evaluation
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
