临床病理因素与警淋巴结阳性与乳腺癌使用绿色氨酸相关的临床病理因素:在秘鲁进行的一项回顾性研究
Gastón Wilmer Mendoza De Lama1, Nancy Elena Muñoz Quispe2, Jorge Marcelo Aguilar Cosme2
1Detecta Clínica, Lima, Peru. investigacion@detecta.pe.
World journal of surgical oncology
|February 7, 2026
概括
这项研究表明,瘤大小,pT阶段和淋巴血管入侵预测了乳腺癌患者接受氨酸绿导向哨兵淋巴结活检 (SLNB) 的淋巴结阳性. 这一秘鲁系列支持SLNB作为安全有效的乳腺癌治疗方法.
科学领域:
- 在瘤学瘤学.
- 手术创新 在外科创新.
背景情况:
- 使用绿色氨酸 (ICG) 的哨兵淋巴结活检 (SLNB) 是乳腺癌分期的高收益技术.
- 关于拉丁美洲的ICG指导的SLNB存在有限的数据.
- 本研究介绍了秘鲁首次使用ICG指导SLNB的经验.
研究的目的:
- 描述秘鲁的ICG指导的SLNB的初始系列.
- 为了评估ICG指导的SLNB的疗效.
- 为了确定与淋巴结阳性相关的临床病理因素.
主要方法:
- 69名接受ICG指导SLNB (2021-2024) 的乳腺癌患者的回顾性分析.
- 临床和病理变量的评估.
- 两变量和多变量统计测试以评估与淋巴结阳性相关的关系.
主要成果:
- 实现了ICG引导SLNB的100%检测率.
- 报告的高性能指标:灵敏度 (96.9%),特异性 (97.3%),PPV (96.9%) 和NPV (97.3%).
- 淋巴结积极性的重要预测因素包括较大的瘤大小,晚期PT阶段和淋巴血管入侵.
结论:
- 瘤大小,pT阶段和淋巴血管入侵是秘鲁乳腺癌患者淋巴结阳性的关键预测因素.
- 这项研究为拉丁美洲实施ICG指导的SLNB提供了关键证据.
- 由ICG指导的SLNB被证实是乳腺癌治疗的安全有效方法.
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