阿特拉提洛德斯 (Atractylodes macrocephala) 不溶性食纤维对小鼠洛佩拉胺诱导的功能性便秘的改善作用
Senye Wang1, Wenjing Feng2, Suxing Tu2
1National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China; College of Agriculture, Henan University, Kaifeng 475004, China.
Food research international (Ottawa, Ont.)
|February 7, 2026
概括
阿特拉提洛德斯巨头无溶性食纤维 (AMDF) 通过增强肠道微生物群的多样性,调节新陈代谢和减少炎症来改善功能性便秘 (FC). 在老鼠中,AMDF有效地缓解了便秘症状和结肠组织损伤.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 功能性便秘 (FC) 是一种普遍存在的胃肠道疾病,具有复杂的潜在机制.
- 洛佩拉胺 (LOP) 通常用于诱导研究环境中的便秘模型.
- 包括不溶性纤维在内的饮食干预措施被探索用于管理FC.
研究的目的:
- 在功能性便秘 (FC) 的老鼠模型中研究Atractylodes宏观脑无溶性食纤维 (AMDF) 的治疗机制.
- 评估AMDF对FC大鼠肠道运动,肠道微生物群,新陈代谢和炎症的影响.
主要方法:
- 使用洛佩拉米德化物 (LOP) 建立了一种FC大鼠模型.
- 给FC大鼠使用AMDF,并评估生理和生化参数.
- 16S rDNA测序用于肠道微生物群分析.
- 代谢学分析以确定代谢途径的改变.
- 结肠组织的组织病理学检查和炎症标志物的评估.
主要成果:
- 在FC大鼠中,AMDF显著增加了便中的水含量和小肠过境率.
- 胃肠道激素 (GAS,VIP,SP,SS) 和炎症类细胞因子 (IL-6,TNF-α,NO) 的AMDF调节的血清水平.
- AMDF增强了肠道微生物群的多样性,恢复了Firmicutes/Bacteroids (F/B) 比率,调节了胆酸和氨基酸代谢,抑制了NF-κB信号传递,并减少了结肠炎症.
结论:
- 在大鼠模型中,AMDF在改善功能性便秘方面表现出显著的有效性.
- AMDF的治疗效果归因于改善肠道微生物群组成,代谢调节和抑制肠道炎症.
- 艾美迪夫 (AMDF) 是一种有前途的天然纤维干预措施,用于控制功能性便秘.
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