耐药的德克斯特林/桑坦凝保护益生菌,用于电离辐射屏蔽
Minting Wang1, Rui Sun2, Liuchan Zeng1
1Guangdong Pharmaceutical University, Guangzhou 510006, China; Beijing Institute of Radiation Medicine, Beijing 100850, China.
Food research international (Ottawa, Ont.)
|February 7, 2026
概括
耐药的德克斯特林和香形成凝来保护益生菌,改善肠道健康并减少辐射损伤. 这种新型食品凝可以保护益生菌,增强它们对辐射肠炎和血液形成性急性辐射综合征的有效性.
科学领域:
- 食品科学与技术 食品科学与技术
- 微生物学 微生物学
- 辐射生物学 辐射生物学
背景情况:
- 益生菌提供健康益处,但受到胃部恶劣状况和肠道殖民不良的限制.
- 耐药德克斯特林 (RD) 和香甘 (XG) 是食品添加剂,其功能尚未完全理解.
- 开发有效的益生菌输送系统对于最大限度地发挥其治疗潜力至关重要.
研究的目的:
- 开发一种新的复合食品凝 (MRX),用于同时提供多菌株益生菌 (MSP).
- 评估MRX对辐射诱导的肠道损伤和造血综合征的保护作用.
- 研究MRX对肠道微生物群恒温和短链脂肪酸生产的影响.
主要方法:
- 使用RD和XG来创建密集的凝矩阵,用于加载Bacillus coagulans (Bc) 和Lactobacillus reuteri (Lr).
- 评估了MRX凝的抗酸性,粘附性和益生菌保护能力.
- 在小鼠中评估了口服MRX在预防和治疗辐射肠炎 (RE) 和血液形成性急性辐射综合征 (H-ARS) 的疗效.
主要成果:
- 该MRX凝表现出优异的抗酸性和粘附性,保护充满益生菌.
- 口服MRX显著缓解了辐射诱导的肠道损伤,炎症和屏障功能障碍.
- 在被辐射的小鼠中,MRX改善了肠道微生物群的稳态,增强了短链脂肪酸的产生,降低了死亡率,并保护了造血系统.
结论:
- 复合RD/XG凝作为益生菌的有希望的载体,增强其稳定性和有效性.
- 作为放射性保护剂和治疗辐射引起的胃肠道疾病的治疗策略,MRX显示出显著的潜力.
- 这种方法提供了一种新的策略,用于屏蔽电离辐射和管理其他肠道疾病.
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