用于治疗性结肠炎的素硫酸功能化素纳米颗粒:提高疗效和机制探索
Dan Zhang1, Li-Hang Chen1, Tao Chen1
1SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Food research international (Ottawa, Ont.)
|February 7, 2026
概括
含有黄素的纳米粒子通过减少炎症和修复肠道内膜,有效地治疗小鼠的性结肠炎 (UC). 这种新型的输送系统增强了黄素的功效.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 黄素 (CUR) 具有抗炎性质,但其生物利用性较差.
- 需要新的药物输送系统来提高CUR对UC的治疗疗效.
研究的目的:
- 开发和描述CUR载荷纳米粒子 (OCC NPs) 使用烯酸和二硫酸盐 (CS).
- 在UC的小鼠模型中评估OCCNP的抗炎和治疗作用.
主要方法:
- 合成和CUR载荷纳米粒子 (OCCNP) 的表征.
- 在模拟的胃肠道液体中评估纳米粒子稳定性.
- 在化学诱导的UC小鼠模型中对OCCNP的体内评估.
- 对炎症标记物,巨细胞激活和粘膜屏障蛋白质 (ZO-1,Claudin) 的分析.
- 对潜在的抗炎途径 (TLR4/MyD88/NF-κB) 的研究.
主要成果:
- OCC NPs的尺寸大约为239nm,稳定性良好.
- CS修改增强了巨细胞向和抗炎/抗氧化活性.
- OCC NPs显著缓解了UC症状,减少了结肠炎症,并改善了粘膜屏障功能.
- 治疗上调了ZO-1和Claudin的表达,表明屏障修复.
- 通过抑制TLR4/MyD88/NF-κB通路和减少促炎细胞因子来调解抗炎作用.
结论:
- 基于烯酸和氏丁硫酸盐的纳米颗粒有效地为UC治疗提供黄素.
- 通过减少炎症和恢复肠道屏障完整性,OCC NPs显示出显著的治疗潜力.
- 这项研究强调了一种有前途的纳米医学方法来治疗性结肠炎.
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