黑中的普罗基亚尼丁C1调节代谢-炎症轴,以对抗动脉样硬化中的血管衰老
Min Li1, Jia-Yao Si2, Peng-Fei Xie2
1School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China; School of Food Science, NanJing Xiaozhuang University, Nanjing 210023, China.
Food research international (Ottawa, Ont.)
|February 7, 2026
概括
黑中的Procyanidin C1 (PCC1) 通过清除衰老细胞和抑制炎症通路,有效地对抗动脉样硬化. 这种天然化合物向热冲击蛋白90 (HSP90),为老年人群提供血管保护性益处.
科学领域:
- 心血管研究研究心血管研究
- 生物老龄化生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 全球老龄化增加了动脉样硬化 (AS) 风险,使血管衰老成为关键的治疗目标.
- 普罗基亚尼丁C1 (PCC1),一种棘多,表现出老化和延长寿命的特性.
- 棘寡合物益氨酸 (HOPCs) 和PCC1在对抗与年龄相关的血管疾病方面表现有前途.
研究的目的:
- 研究PCC1在动脉样硬化中的调节作用和机制.
- 评估PCC1和HOPCs的抗动脉样硬化和抗衰老作用.
- 为了确定受PCC1在血管衰老中影响的分子标和途径.
主要方法:
- 使用高脂肪饮食 (HFD) 的ApoE-/-小鼠模型和D-银糖 (D-Gal) 诱导的细胞衰老模型.
- 进行了代谢分析,药物亲和度响应目标稳定性 (DARTS),LC-MS/MS,CETSA和分子对接.
- 进行了体外研究,以评估衰老细胞清除,SASP抑制,eNOS酸化和TLR2/NF-κB通路抑制.
主要成果:
- PCC1和HOPCs减少了大动脉根斑块,改善了脂质新陈代谢,并减少了血管衰老标志物和炎症分子.
- PCC1抑制了阿拉基酸 (AA) 的新陈代谢,减少了促炎媒介.
- 确定了热冲击蛋白90 (HSP90) 作为PCC1的直接标,抑制下游信号传输和TLR2/NF-κB通路.
结论:
- 通过衰老细胞清除和TLR2/NF-κB信号轴的HSP90介导阻塞,PCC1减轻动脉样硬化.
- PCC1表现出多式抗衰老和抗炎作用,包括SASP抑制和eNOS激活.
- PCC1是一种有前途的血管保护剂,支持在功能性食品中使用棘提取物,以促进心血管健康.
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