长期化疗诱导的周围神经病变使用患者报告的妇科恶性瘤结果来评估
Chikage Narui1, Hiroshi Tanabe1,2, Masataka Takenaka1
1Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
Journal of gynecologic oncology
|February 7, 2026
概括
在妇科癌症幸存者中,化疗诱导的周围神经病变 (CIPN) 可能会改善,但在治疗帕克利塔塞尔和卡博普拉丁 (TC) 后,长期治疗通常不会完全消失. 用患者报告的结果 (PROs) 来评估长期CIPN结果.
科学领域:
- 在瘤学瘤学.
- 妇科瘤学 妇科瘤学
- 神经瘤学神经瘤学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是妇科癌症幸存者的常见和具有挑战性的副作用.
- 对于CIPN的长期结果和解决模式的理解仍然不完全.
- 患者报告结果 (PRO) 为评估与治疗相关的副作用 (如CIPN) 提供了有价值的工具.
研究的目的:
- 为了评估CIPN在接受帕克利塔克塞尔和卡博普拉丁 (TC) 治疗的妇科癌症患者的长期结果.
- 通过患者报告的结果 (PROs) 来评估CIPN的解决轨迹.
主要方法:
- 一组616名妇科癌症患者 (卵巢,子宫体,宫等). 分析了手术后的情况.
- 患者被分为TC化疗组 (304) 和无化疗对照组 (312).
- 通过癌症治疗/妇科瘤学组-神经毒性 (FACT/GOG Ntx) 功能评估子规模 (PRO) 和国家癌症研究所医生评级的不良事件常用术语标准 (NCI-CTCAE) 来评估CIPN.
主要成果:
- 在TC组中,根据FACT/GOG Ntx评估的CIPN分数随着时间的推移显著下降 (p<0.001).
- 在治疗后5年,TC组的CIPN得分仍然明显高于没有化疗组的CIPN得分 (p=0.040).
- NCI-CTCAE的评估显示了类似的趋势,表明持续的CIPN.
结论:
- 在TC治疗后的CIPN可能会在长时间内改善.
- 在所有接受TC治疗的妇科癌症幸存者中,CIPN可能不会完全消失.
- 使用PRO的长期监测对于了解癌症幸存者的CIPN至关重要.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
790
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
790
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
899
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
899
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
682
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
682
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
627
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
627
Data Reporting and Recording
5.5K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.5K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
451
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
451


