波马利多米德,环胺和甲 (PCd):双重或三重阻断性多发性髓瘤患者的结局
Marta Hidalgo-Soto1, Luis Gerardo Rodríguez-Lobato1,2, Cristina Motlló Borrella3
1Haematology Department, Instituto de Investigaciones Biomédicas August pi i Sunyer (IDIBAPS), Barcelona, Spain.
European journal of haematology
|February 7, 2026
概括
波马利多米德,环胺和德克萨米他 (PCd) 疗法在治疗耐火性多发性髓瘤 (RRMM) 中显示出有效性. 这项研究证实PCd是双重和三重耐药RRMM患者的可行选择,即使这些患者对其他疗法有抗性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 耐火性多发性骨髓瘤 (RRMM) 提出了重大治疗挑战.
- 对于患有双重和三重耐药性疾病的患者,有效选择有限.
研究的目的:
- 为了评估波马利多米德,环胺和甲 (PCd) 治疗方案的疗效和安全性.
- 评估PCd在RRMM患者中的活性,包括对lenalidomide和抗CD38疗法耐药的患者.
主要方法:
- 追溯性,多中心研究设计.
- 包括179名用PCd治疗的RRMM患者.
- 对整体反应率 (ORR),无进展生存率 (PFS) 和整体生存率 (OS) 的分析.
主要成果:
- 总体反应率 (ORR) 为59.8%.
- 中位数PFS为7.9个月,中位数OS为16.1个月.
- 常见的3-4级不良事件包括中性质减退 (57.5%),贫血 (30.7%) 和血小板减退 (29.6%).
结论:
- 该PCd疗法在患有双重和三重耐火性RRMM的患者中显示出有效性.
- 对于RRMM患者来说,PCd是一种可行的治疗选择,包括那些对莱纳利多米德和抗CD38药物耐药的人.
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