献血者的中性粒细胞反应性自身抗体:我们可以期待TRALI吗?
Stefanie Jehle1, Darvin Preuss1, Yannick Waxmann1
1Institute for Clinical Immunology, Transfusion Medicine, and Haemostaseology, Justus-Liebig-University, Giessen, Germany.
Transfusion
|February 7, 2026
概括
输血血液中的中性粒细胞自身抗体可能通过激活中性粒细胞和增加内皮透性,导致输血相关的急性肺损伤 (TRALI). 需要进一步的研究来证实它们在TRALI开发中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 肺部医学 肺部医学
背景情况:
- 与输血相关的急性肺损伤 (TRALI) 是与输血相关的死亡的一个重要原因,其特征是急性肺.
- 虽然含有alloantibodies,但在TRALI病例中也检测到捐赠者的中性粒细胞自身抗体.
- 这些自身抗体在TRALI病变发生过程中的潜在作用尚不清楚.
研究的目的:
- 调查献血者的中性粒细胞自身抗体是否可以促进TRALI的发展.
- 在体外评估这些自身抗体对中性粒细胞和内皮细胞的功能作用.
主要方法:
- 分析了来自TRALI捐赠者的血清,这些血清没有特定的代抗体,但具有暗示性中性粒细胞自身抗体 (n=12).
- 试验评估了补充结合,中性粒细胞激活 (ROS产生) 和内皮屏障破坏 (白蛋白流入) 与中性粒细胞和没有中性粒细胞.
主要成果:
- 12个TRALI血清中的2个诱导了中性粒细胞中的活性氧物种 (ROS).
- 这两种血清还增加了内皮透性在存在,但不是缺席的中性粒细胞.
- 这些血清没有观察到补充激活.
结论:
- 中性粒细胞自身抗体可能通过激活中性粒细胞和破坏内皮壁垒,在特定情况下对TRALI作出贡献.
- 这些发现突出了TRALI发展的可能机制,涉及自身抗体.
- 需要进一步的研究,以充分阐明中性粒细胞自身抗体在TRALI中的功能影响.
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