20年的经验与脱细胞化肺同体移植为肺置换的肺
Samir Sarikouch1, Boethig Dietmar1,2, Avsar Murat1
1Department for Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Germany.
概括
脱细胞化肺同体移植 (DPH) 在先天性心脏病中为肺置换提供了有利的长期结果. 然而,门功能在20年内下降,这表明可能需要改进脱细胞化技术.
科学领域:
- 心血管外科心血管外科
- 生物材料科学 生物材料科学
- 遗传性心脏病治疗方法 治疗方法
背景情况:
- 自2005年以来,脱细胞化肺同体移植 (DPH) 已在临床上用于肺置换.
- 这项研究评估了先天性心脏病患者的DPH的长期临床结果.
研究的目的:
- 为了总结20年的临床经验,DPH用于肺置换 (PVR).
- 评估DPH在儿科和成人先天性心脏病患者群体中的长期疗效和耐用性.
主要方法:
- 在2005年1月至2025年8月期间接受DPH治疗PVR的310名患者的前性随访.
- 纳入标准包括PVR的标准适应症,但不包括活性内心炎.
- 分析了卡普兰-梅尔生存率和不受不良事件的影响.
主要成果:
- 在20岁时,免于死亡的比例为96.9%,免于扩张的比例为85.2%,免于内心炎的比例为91.0%.
- 门功能呈现下降,没有狭窄和中度吐,到20年达到0%.
- 有限的患者数量可用于超过15年的分析.
结论:
- 与冷保存的同种移植体相比,DPH表现出有利的长期免于扩张的自由.
- 在20多年中,人们观察到门功能显著下降 (缩小和吐).
- 其余免疫性可能会影响DPH功能,表明需要改进脱细胞化方法.
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