伦瓦提尼布对肝功能及其预后意义的早期影响:单中心回顾性研究
Pei Wang1, Shuheng Liu2, Xiaoxia Lu1
1Department of Digestive Medicine, Wuwei People's Hospital, Wuwei City, Gansu Province, 733000, People's Republic of China.
概括
伦瓦提尼布治疗对晚期肝细胞癌 (HCC) 患者的肝功能有轻微影响,但基线肝功能是结果的关键预测因素. 对于肝脏储备受损的患者,密切监测是必不可少的.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 医学瘤学 医学瘤学
- 临床治疗学 临床治疗学
背景情况:
- 晚期肝细胞癌 (HCC) 带来了重大的治疗挑战.
- 伦瓦提尼布是先进的HCC的既定治疗方法,在瘤反应和生存方面表现出有效性.
- 伦瓦提尼布对HCC患者肝功能的影响需要进一步阐明.
研究的目的:
- 评估伦瓦提尼布对晚期HCC患者肝功能的影响.
- 为了评估基线肝功能和治疗反应的预后意义在接受lenvatinib的高级HCC患者.
主要方法:
- 一个单一中心的回顾性队列研究.
- 包括40名患有晚期HCC的患者,接受了lenvatinib≥2个月.
- 评估了白素-白素 (ALBI) 评分的变化和与临床结果相关的基线肝功能.
主要成果:
- 伦瓦替尼治疗导致ALBI得分略微但统计学上显著增加,这表明对肝功能的影响最小.
- 平均总生存时间为22.8个月,平均无进展生存时间为12.7个月.
- 原始肝功能受损与不良临床结果有显著的关联,而治疗反应是独立的预后因素.
结论:
- 基线ALBI得分是用lenvatinib治疗的晚期HCC患者的关键预后标记.
- 仔细监测肝功能是必要的,特别是在已经存在肝损伤的患者中.
- 伦瓦提尼布对肝功能的影响似乎是可控的,但基线状态对于预测患者预后至关重要.
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