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相关概念视频

Drag Force and Terminal Speed01:18

Drag Force and Terminal Speed

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An interesting force in everyday life is the force of drag on an object when it is moving in a fluid. Like friction, the drag force always opposes the motion of an object. Unlike simple friction, the drag force is proportional to some function of the velocity of the object in that fluid. This functionality is complicated and depends upon the shape of the object, its size, its velocity, and the fluid it is in. For most large objects, such as cyclists, cars, and baseballs, that are not moving too...
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Atomic Force Microscopy01:08

Atomic Force Microscopy

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Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
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Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

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The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
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Resonance02:52

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The Lewis structure of a nitrite anion (NO2−) may actually be drawn in two different ways, distinguished by the locations of the N-O and N=O bonds.
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Atomic Orbitals02:44

Atomic Orbitals

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An atomic orbital represents the three-dimensional regions in an atom where an electron has the highest probability to reside. The radial distribution function indicates the total probability of finding an electron within the thin shell at a distance r from the nucleus. The atomic orbitals have distinct shapes which are determined by l, the angular momentum quantum number. The orbitals are often drawn with a boundary surface, enclosing densest regions of the cloud.
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Intermolecular Forces03:13

Intermolecular Forces

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Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
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相关实验视频

Updated: Feb 8, 2026

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping
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High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping

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高速集成非共振原子力显微镜

Kaixuan Wang1,2, Jialin Shi1, Peng Yu1

  • 1State Key Laboratory of Robotics and Intelligent Systems, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China.

Nano letters
|February 7, 2026
PubMed
概括
此摘要是机器生成的。

科学家们开发了用于原子力显微镜 (AFM) 的整体非共振敲击 (I-ORT) 模式. 这种新方法显著加快了动态材料的成像,而不会损失数据质量.

关键词:
原子力显微镜的原子力显微镜.高速成像技术的使用.纳米机械的表征.在非共振的触摸下,响应外的触摸.粘性弹性材料是一种粘性弹性材料.

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Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope

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Last Updated: Feb 8, 2026

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Force Spectroscopy of Single Protein Molecules Using an Atomic Force Microscope
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科学领域:

  • 材料科学 材料科学 材料科学
  • 纳米技术 纳米技术
  • 生物材料科学 生物材料科学

背景情况:

  • 原子力显微镜 (AFM) 能够同时进行机械绘图和地形特征.
  • 在AFM中,Off-resonance tapping (ORT) 模式提供了双重功能,但由于闭环延迟和有限的稳定性,其成像速度较低.
  • 研究动态标本是当前ORT模式限制的挑战.

研究的目的:

  • 为了提高AFM中ORT模式的成像速度.
  • 为了克服传统ORT模式的局限性,特别是闭环延迟和稳定性.
  • 为了实现动态材料和生物材料的高速表征.

主要方法:

  • 开发了一个完整的非共振敲击 (I-ORT) 模式用于AFM.
  • 取代固定点采样,采用基线以上的相互作用曲线的积分采样.
  • 保持与传统ORT模式相同的驱动和传感条件.

主要成果:

  • 与传统的ORT模式相比,扫描速度提高了10倍.
  • 保持了机械性能表征的质量.
  • 减轻了来自探头样本相互作用的不可预测干扰.

结论:

  • I-ORT模式显著提高了AFM成像的速度.
  • 这一进步克服了以前的局限性,使动态标本的研究成为可能.
  • 通过提供更快,高分辨率的表征,I-ORT模式支持高端纳米技术研究.