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Updated: Feb 8, 2026

Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI
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在现场衍生结合DESI-MRM-MS/MS用于空间映射内组织氨基含有代谢物,三甲基胺作为一个案例

Zhihao Zhou1, Kangrui Hu1, Nan Jia1

  • 1Key Laboratory of Drug Metabolism & Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China.

Analytical chemistry
|February 7, 2026
PubMed
概括

一种新的现场衍生方法提高了对含氨酸代谢物的质谱成像灵敏度. 这项技术可视化了小鼠大脑中的三甲基胺分布,揭示了老年动物的积累.

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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