突变L-asparaginase的囊蛋白化提供了增强的活性和热稳定性. 对N端结合的比较研究

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Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry
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Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry

Published on: May 27, 2018

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Rafael B Ferraro1,2, Guilherme R Benevides1, Jheniffer Rabelo1

  • 1Department of Biochemical Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.

Applied biochemistry and biotechnology
|February 7, 2026
PubMed
概括

这项研究通过探索Cys206和N-终端基化位点来优化L-阿斯巴拉金酶 (ASNase) 的生物效应. 囊素基化 (Cys-PEG-ASNase) 增强了酶活性和稳定性,比N端基化 (NT-PEG-ASNase) 更有效.

关键词:
酶活性的酶活性.酶的稳定性 酶的稳定性在L-asparaginase的使用中.化 化 化 化热力学是一种热力学.热稳定性 热稳定性

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