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Updated: Feb 8, 2026

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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对针对DLL3的CD3双特异抗体的结构和功能洞察力在癌症免疫治疗中针对DLL3

Shanshan Chen1, Guangshun Zhang1, Xiangyi He1

  • 1RemeGen (Shanghai) Co., Ltd, Building 25, Lane 588, Tianxiong Road, Zhoupu Town, Shangha, 201318, China.

Medical oncology (Northwood, London, England)
|February 7, 2026
PubMed
概括

针对三角形样联体3 (DLL3) 的CD3双特异性抗体 (BsAbs) 在癌症免疫治疗中显示出前景. 免疫突触距离和表皮质结合等结构特征与有效性和安全性密切相关,指导药物优化.

关键词:
CD3双特异性抗体 CD3双特异性抗体免疫突触的突触发生.免疫瘤学 免疫瘤学结构生物学是结构生物学.T细胞的功能是T细胞的功能.

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