纤维肌痛中的神经纤维光链:与中枢和外围神经系统功能障碍的相关性
Maddalena Ruggieri1, Concetta Domenica Gargano1, Giulia Paparella1,2
1Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy.
European journal of pain (London, England)
|February 7, 2026
概括
血清神经丝光链 (NfL) 在纤维肌痛患者中升高,表明神经元发生变化. 然而,NfL水平与小纤维病理或认知问题无关,这表明它反映了整体疾病负担,而不是特定的神经损伤.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 疼痛医学 医学 疼痛医学
背景情况:
- 纤维肌痛 (FM) 是一种慢性疼痛疾病,通常与中心敏感和小纤维病理有关.
- 神经纤维光链 (NfL) 是轴突损伤的生物标志物,但其在FM中的特定作用尚不清楚.
- 在FM中调查NfL可能会为该疾病的潜在神经生物学提供见解.
研究的目的:
- 为了评估纤维肌痛患者与健康对照人群相比,血清NfL水平.
- 探索NfL水平和临床特征之间的相关性,包括疼痛,残疾,睡眠和认知功能.
- 评估NfL水平与通过皮肤活检确定的小纤维病理之间的关系.
主要方法:
- 进行了一项观察性病例控制研究,对70名 FM 患者和55名健康对照进行了观察.
- 血清NfL使用LUMIPULSE G600II平台进行了量化.
- 临床评估包括针对疼痛,残疾,睡眠和认知功能 (MoCA,执行功能电池) 的验证问卷;40名患者进行皮肤活检以评估皮内神经纤维密度 (IENFD).
主要成果:
- 纤维肌痛患者的血清NfL水平明显高于对照组,无论年龄如何.
- 血清NfL水平与两组患者的年龄呈正相关性,但与 FM 患者的 IENFD 或皮肤活检结果没有相关性.
- FM 患者的 NfL 水平与疾病持续时间,疼痛强度,睡眠质量或认知表现无关,但确实与残疾 (FIQ 分数) 有正相关性.
结论:
- 在纤维肌痛中血清NfL升高表明疾病中存在神经性成分.
- 血清NfL与小纤维病理或FM的认知障碍没有直接联系.
- 虽然NfL可能作为神经元应激或疾病负担的潜在生物标志物,在慢性疼痛疾病如纤维肌痛中,但并不特定于外围神经损伤.
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