相关实验视频

Updated: Feb 9, 2026

Mitochondrial Respiration Quantification in Yeast Whole Cells

Mitochondrial Respiration Quantification in Yeast Whole Cells

Published on: November 8, 2024

动态重编程线粒体呼吸以增加癌症治疗中的cuproptosis

Haohan Zhou¹, Ruijue Wang^2,3, Fang Zhu⁴

¹Department of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Small (Weinheim an der Bergstrasse, Germany)

|February 7, 2026

概括

这项研究引入了一种新型的纳米粒子,该纳米粒子提供乳酸氧化酶来重编程癌细胞代谢,增强铜诱导的细胞死亡 (亡) 并促进抗瘤作用.

科学领域:

生物化学生物化学
细胞生物学细胞生物学
在瘤学瘤学.

背景情况:

型亡是一种新发现的受调节的细胞死亡途径,依赖于铜离子和线粒体呼吸.
代谢重编程是癌症治疗的一个关键策略.
乳酸氧化酶在调节细胞能量代谢方面发挥作用.

研究的目的:

为了研究乳酸氧化酶在cuproptosis中的作用.
开发一种纳米粒子,可将乳酸氧化酶向癌细胞.
探索代谢重编程在癌症治疗中的潜力.

主要方法:

开发用于乳酸氧化酶输送的铜协调聚合物纳米粒子.
评估纳米粒子对癌细胞代谢的影响,包括酸盐脱酶和酸盐激酶活性.
评估纳米粒子诱导的杯和铁.
在体内对抗瘤功效的研究.

主要成果:

纳米粒子有效地将乳酸氧化酶输送到癌细胞中,通过将乳酸转化为酸盐来重新编程能量代谢.
代谢重编程促进了线粒体功能,通过DLAT寡合化和TCA循环中断促进了cuproptosis.
纳米粒子通过不同的机制诱导了cuproptosis和ferroptosis.
在体内观察到显著的抗瘤疗效.

结论:

通过纳米颗粒传递乳酸氧化酶有效地重新编程癌细胞代谢以诱导cuproptosis.
这种方法提供了一种新的治疗策略,利用代谢漏洞来治疗癌症.
cuproptosis和ferroptosis的双重诱导为增强抗瘤活性提供了一个有希望的途径.

关键词:

聚合物的协调性聚合物.这就是cuproptosis.乳酸氧化酶是什么乳酸氧化酶线粒体呼吸系统的呼吸过程纳米医药是一种纳米医药.

更多相关视频

An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes

An Optimized Protocol to Analyze Glycolysis and Mitochondrial Respiration in Lymphocytes

Published on: November 21, 2016

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Real-time Monitoring of Mitochondrial Respiration in Cytokine-differentiated Human Primary T Cells

Published on: October 19, 2021

相关概念视频

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Respiration

Respiration

Overview of the Respiratory System and Energy Production
Energy production in the human body is primarily fueled by oxidation, a process where food molecules are burned by combining with oxygen to produce carbon dioxide and water. This vital metabolic process sustains life, and is supported intricately by the respiratory system.
Structure and Function of the Respiratory System:
The respiratory system is a complex network of structures that includes the nose, oropharynx, larynx, trachea,...

Animal Mitochondrial Genetics

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...

Alterations in Respiration II

Alterations in Respiration II

There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...

Respiration Pathways

Respiration Pathways

Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...