佩拉戈尼 (Pelargonium sidoides) - - 从民族药理学到基于证据的医学:一个系统性审查
Oksana Honchar1, Olha Мykhailenko2, Olha Holovchenko3
1Pharmaceutical Chemistry Department, National University of Pharmacy, Kharkiv, Ukraine; Department of Chemical and Pharmaceutical Disciplines, Rivne Medical Academy, Rivne, Ukraine.
概括
南非的一种草药Pelargonium sidoides有效治疗呼吸道感染. 它的传统用途现在得到了现代科学的验证,显示了其作为标准化植物医药的潜力.
科学领域:
- 植物医学和民族植物学
- 药理学和分子生物学
背景情况:
- 佩拉戈尼 (Pelargonium sidoides) (Geraniaceae) 在南部非洲有着传统的用于呼吸道和胃肠道疾病的历史.
- 它已经发展成为药物产品Umckaloabo (EPs® 7630),将传统知识与基于证据的治疗方法相结合.
研究的目的:
- 系统地分析Pelargonium sidoides,涵盖其植物学,民族植物学,以及作为受监管的植物医药的发展.
- 合成其植物化学特征,作用机制,培养和对呼吸道感染的临床疗效.
主要方法:
- 在2025年12月之前,使用PubMed,Scopus和Cochrane图书馆进行了系统的文献搜索.
- 遵循了PRISMA的指导方针,包括科学文章,药典,专利和民族植物记录.
主要成果:
- 标志着P. sidoides的化学多样性,包括类,类,类和类硫酸盐.
- 总结了种植,提取技术和分析方法 (HPLC,LC-MS,TLC).
- 证明了多目标药理活性 (免疫调节,抗菌,抗病毒) 和经过验证的临床疗效急性支气管炎,鼻炎和桃腺炎.
结论:
- 在医疗保健中P. sidoides的整合得到了传统知识和科学验证的支持.
- P. sidoides作为将民族植物资源转化为标准化,基于证据的植物医学的模型.
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