在患有多发性硬化症的老年人中,腿部强度和神经激活缺陷
Yinan Zhang1, Fernanda L Schumacher2, Leatha A Clark3
1Department of Neurology, College of Medicine, The Ohio State University, USA.
Multiple sclerosis and related disorders
|February 7, 2026
概括
患有多发性硬化症 (MS) 的老年人由于神经活化受损而感到虚弱,而不是肌肉质量下降. 这项研究阐明了MS中神经肌肉变化,将其与与年龄相关的衰退区分开来.
科学领域:
- 神经肌肉生理学 神经肌肉生理学
- 衰老的研究研究.
- 神经免疫学 神经免疫学
背景情况:
- 多发性硬化症 (MS) 涉及免疫介导的炎症和神经退行,导致虚弱和运动问题.
- 在临床上,区分MS相关的弱点与老年人与年龄相关的变化是具有挑战性的.
- 了解神经肌肉机制对于解决MS老年人的弱点至关重要.
研究的目的:
- 为了研究与年龄相关的肌肉力量下降的神经肌肉机制与MS的老年人.
- 为了比较老年人的神经激活,肌肉体积和收缩质量,有或没有MS.
- 确定这些因素对患有多发性硬化症的老年人衰弱的贡献.
主要方法:
- 比较了膝盖延伸器的自愿激活,MRI衍生的肌肉体积和骨肌肉收缩质量.
- 研究了10名患有多发性硬化症的老年人和10名年龄,性别和BMI匹配的对照.
- 使用非参数统计分析进行群组比较.
主要成果:
- 患有多发性硬化症的参与者表现出相对于体重和肌肉体积的力量减少.
- 四头肌体积在各组之间是相似的,但收缩质量在MS中较低.
- 神经激活在MS中减少,由较低的中央激活弹道扭矩 (CAB) 比率和自愿激活表明.
结论:
- 患有多发性硬化症的老年人的神经肌肉缺陷主要是由于神经活化受损.
- 在患有MS的老年人和对照人群之间,肌肉质量没有显著差异.
- 研究结果强调神经激活缺陷是MS相关弱点的关键因素.
相关概念视频
01:23Muscles that Move the Leg
5.3K
The movement of the legs is facilitated by numerous muscles located within the anterior, medial, and posterior compartments of the thigh.
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed...
5.3K
03:05Acid Strength and Molecular Structure
33.1K
Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
33.1K
01:20Strength of Cement
506
Strength tests for cement are not performed directly on neat cement paste due to difficulty in obtaining consistent, reliable specimens. Instead, cement is typically tested in the form of cement-sand mortar.
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in...
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in...
506
01:30Relation Between Tensile Strength and Compressive Strength of Concrete
690
Concrete is a fundamental building material, and understanding its strengths is crucial for construction projects. The relationship between its tensile and compressive strengths is intricate, showing that while these strengths are related, they do not increase at the same rate. Tensile strength's growth is slower and is affected by various factors such as the methods used for testing, the size and shape of the specimen, the texture of the aggregate used, and the moisture content of the...
690
02:18The Equilibrium Binding Constant and Binding Strength
15.1K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.1K
01:30Attention-Deficit/Hyperactivity Disorder
1.0K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.0K