上部通道静脉入侵泌尿道癌:诊断特征和瘤结局
Stephan Brönimann1, Zahra Moghimi2, Philipp Korn3
1Department of Urology and Oncology, The Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Urologic oncology
|February 7, 2026
概括
带有静脉瘤血栓的上路泌尿道癌具有侵略性,表现为晚期和类特征. 早期识别成像症状对于诊断和及时多式联络治疗至关重要.
科学领域:
- 尿瘤学 尿瘤学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 带有静脉瘤血栓 (VTT) 的上道泌尿系统癌 (UTUC) 是一种罕见且具有攻击性的疾病.
- 鉴定其临床,放射学和组织病理学特征对于理解其行为和结果至关重要.
研究的目的:
- 描述具有VTT的UTUC的临床,放射和病理学特征.
- 评估那些接受了激进脏切除术 (RNU) 的患者的瘤结局.
主要方法:
- 对接受RNU.VTT的UTUC患者的回顾性分析.
- 由尿生殖系放射科医生对横截面成像的审查.
- 通过尿生殖系统病理学家进行病理学审查.
- 对临床,放射和病理特征以及瘤结果的分析.
主要成果:
- 确定了8名患有UTUC和宏观VTT的患者 (平均年龄74岁).
- 图像显示收集系统缺陷,不规则的加厚和透生长. 静脉干扰扩展到静脉 (63%) 或下腔静脉 (37%).
- 75%的人患有pT4疾病,63%的人患有结节干扰. 类细胞分化 (88%) 富含了thrombi. 71%的人发生了转移,62.5%的人死亡. 一名患者对 pembrolizumab 有反应.
结论:
- 带有VTT的UTUC是一种罕见的,具有先进阶段,结节参与和高患病率的肉类瘤分化异性的侵略性表型.
- 在thrombi中类元素的丰富表明独特的生物学和血管入侵的潜力.
- 识别成像特征有助于诊断,防止错误分类 (例如,作为细胞癌),并指导多式治疗.
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