沙门氏菌Enterica血清型的基因组特征圣保罗从马匹中分离出来的分离物
Tirth Uprety1, Carrie L Shaffer2, Alan Loynachan1
1University of Kentucky Veterinary Diagnostic Laboratory, Lexington, KY, USA.
Veterinary microbiology
|February 7, 2026
概括
新兴的多药耐药沙门氏菌圣保罗菌株在马身上被发现,特别是在肯塔基州的小马身上. 这凸显了持续监测的必要性,以管理与抗菌素耐药性相关的动物和人类健康风险.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物传染病研究研究
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 沙门氏菌病是影响动物和人类健康的重大动物性传染病.
- 早期发现新的沙门氏菌血清型及其耐药性模式对于有效控制疫情至关重要.
研究的目的:
- 在马类病例中描述新出现的沙门氏菌血型和抗菌素耐药性模式.
- 调查马匹新发现的S.Saintpaul菌株的遗传基础和流行病学.
主要方法:
- 隔离和血清定型的沙门氏菌Enteric亚种. 从马类病例 (2018-2025) 中获得的数据.
- 全基因组测序,多位置测序类型 (MLST) 和抗菌感应性测试 (AST).
- 对抗微生物耐药性基因的基因类型分析和等离子体分析.
主要成果:
- 沙门氏菌 Typhimurium,纽波特和1,4,[5],12:i:-是主要的血清型.
- 2025年在肯塔基州中部观察到沙门氏菌圣保罗 (Salmonella Saintpaul) 的显著增加,这与严重的小鹿疾病有关.
- 隔离物显示出多种药物耐药性,在马类沙门氏菌中首次发现了blaCTX-M-32,并与Inci-gamma/K1等离子体有关.
结论:
- 马群中多药耐药性S.Saintpaul的出现构成了相当大的动物和动物感染风险.
- 持续监测和抗菌素耐药性监测对于减轻这些风险至关重要.
- 了解像等离子体这样的遗传元素,驱动抗性是未来控制策略的关键.
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