青春期神经内分泌网络特征和性别差异:一种基于头发的激素网络研究
Xuliang Hou1, Mingjun Xie2, Sanjun Yi1
1Department of Brain and Learning Science, School of Biological Science & Medical Engineering, Southeast University, Nanjing 211189, China; Institute of Child Development and Education, Southeast University, Nanjing 211189, China; Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Nanjing 211189, China.
Psychoneuroendocrinology
|February 7, 2026
概括
青春期涉及复杂的荷尔蒙网络变化,具有明显的男性和女性模式. 这项研究揭示了关键的激素枢纽和相互作用,突出了这一关键发育阶段性差异化的系统基础.
科学领域:
- 神经内分泌学神经内分泌学
- 系统生物学 系统生物学
- 青少年发展 青少年发展
背景情况:
- 青春期涉及重要的神经内分泌和神经调节系统重塑.
- 虽然研究了个别的荷尔蒙系统,但在青春期的跨系统协调和性别特异性模式仍然不清楚.
研究的目的:
- 在青春期建立和分析一个全面的荷尔蒙网络.
- 为了确定关键的激素相互作用和枢纽.
- 为了研究荷尔蒙网络组织中的性别特异.
主要方法:
- 招募了449名健康的青少年 (226名男性,223名女性).
- 构建了一个激素网络,包括来自HPA,HPG,ECS和黑激素系统的激素,通过头发中的LC-MS/MS测量.
- 分析了网络属性,如全球强度,预期影响力 (EI) 和桥梁EI,使用网络比较测试检查性别差异.
主要成果:
- 青春期激素网络显示了代谢激素对和对抗性跨系统关联之间的强烈合.
- 皮质醇,丸激素和黑激素被确定为中心中心,丸激素是青春期的特定节点.
- 男性的全球网络强度明显高于女性,在特定边缘重量和NAS和1-AG等关键节点的影响方面存在显著的性别差异.
结论:
- 青春期的特点是增加神经内分泌的整合和性别特定的网络重组.
- 皮质醇和黑激素充当一致的枢纽,而和孕激素则扮演性别差异化的角色.
- 1-AG可能起到抑制性激素的作用,网络分析对于了解青春期性差异是有价值的.
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