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Updated: Feb 9, 2026

Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes
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不平衡的Polycomb复合物的染色体结合导致神经发育障碍

Rodrigo L Borges1, Gretter González-Blanco1, Harikumar Arigela1

  • 1Sylvester Comprehensive Cancer Center, Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL 33136, USA; Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Molecular cell
|February 7, 2026
PubMed
概括

在RING1和RNF2 (E3结合酶) 中的突变与神经发育障碍 (NDD) 有关. 这些突变破坏了多合体抑制复合体1 (PRC1) 活动,影响儿童的大脑发育和功能.

关键词:
多重复合的多重复合.表观遗传学是指表观遗传学.遗传变异是一种遗传变异.神经发育障碍 神经发育障碍神经发生神经发生.干细胞是干细胞的组成部分.

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