淋巴细胞的改变和补充信号的升高是耐火性肌痛严重症的关键特征
Katherine C Dodd1, Kirsten Baillie2, James K L Holt3
1The Lydia Becker Institute for Immunology and Inflammation, University of Manchester, Manchester M13 9NT, UK; Manchester Centre for Clinical Neurosciences, the Northern Care Alliance NHS Foundation Trust, Salford M6 8HD, UK.
耐火性骨髓灰质炎 (MG) 与特定的免疫细胞变化有关,包括更多的记忆B细胞和更少的调节性T细胞. 这些发现可能会揭示MG患者治疗耐药性的生物标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 骨髓灰质炎 (MG) 患者经常抵制标准治疗,缺乏指导的生物标志物.
- 调查耐火性MG中不同的循环免疫特征至关重要.
研究的目的:
- 为了识别与治疗不耐药的肌痛性骨髓灰质炎相关的独特免疫特征.
- 探索潜在的生物标志物来预测MG的治疗反应.
主要方法:
- 从乙胆受体抗体阳性MG患者的外周血液的综合免疫表型.
- 耐火性MG患者与健康对照者的比较和对抗CD20治疗后B细胞复合的评估.
主要成果:
- 耐火性MG显示记忆B细胞增加,IL-6和TNF-α的产生增加,调节性T细胞 (Tregs) 和树突细胞减少.
- 在耐火性MG中观察到补充蛋白和受体的升高.
- 在有限的样本中,低基线B细胞频率与较差的瑞图西马布反应相关.
结论:
- 一个明显的免疫特征是耐火性MG的特征.
- 治疗耐药性的潜在生物标志物包括免疫细胞概况和补充水平.
- 针对血细胞,IL-6补充和Tregs的治疗策略对耐火性MG有希望.
更多相关视频
08:25Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
Published on: November 21, 2018
05:54MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
相关概念视频
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Freezing Point Depression and Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
Complement System
Complementation Tests
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Key Techniques in Microbiology
