孕产妇BCAA营养过多计划在瘦成年后代中持续性失糖症
Joyce Tzeng1, Ismael Ferrer2, Damaris N Lorenzo2
1Department of Cell and Developmental Biology, Perelman School of Medicine. University of Pennsylvania, Philadelphia, PA, USA; Department of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
孕妇在怀孕期间过度摄取分支链氨基酸 (BCAA),为代谢功能障碍的后代进行计划. 后代表现出葡萄糖不耐受性和代谢途径的改变,表明营养特异性发育编程的持久影响.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 母亲的营养显著影响后代的代谢健康.
- 母亲过度摄入特定营养素,如分支链氨基酸 (BCAA) 的影响尚不清楚.
研究的目的:
- 为了研究母亲的BCAA丰富饮食对后代的长期代谢后果.
- 阐明由母亲过度营养引起的发育规划的潜在机制.
主要方法:
- 在怀孕和哺乳期间,小鼠母被食一种同热量,与蛋白质匹配的饮食,富含BCAA.
- 在和高脂肪饮食条件下,评估了后代的代谢概况,葡萄糖稳定性和组织特异性代谢途径.
- 分析了肝脏PGC-1α的表达和活性,作为一种关键的代谢调节剂.
主要成果:
- 孕产妇BCAA过度营养导致高血糖,并改变了母体的氨基酸样本.
- 后代在食中表现出持久的葡萄糖不耐受,高血糖和胰岛素反应的性别差异.
- 在高脂肪饮食挑战下,后代表现出对脂肪的保护,但加剧了高血糖症,与改变的脂肪组织脂解,肝氧化和葡萄糖生成有关.
- 肝脏PGC-1α升高被确定为一个中心调解者,解脂和葡萄糖代谢.
结论:
- 过多的母体BCAA摄入量在发育规划中起到营养特异性的作用.
- 这种编程将脂肪与血糖控制脱离,从而产生对代谢功能障碍的倾向.
- 氨基酸驱动的代谢可塑性是代际代谢健康的关键因素.
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