抗菌酸盐水凝涂层复合骨质水泥珠用于治疗骨髓炎和再生
Arthi Chandramouli1, Riya Babu1, Kavitha Gopal2
1Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, 682041, India.
International journal of biological macromolecules
|February 7, 2026
概括
新的复合骨质水泥珠 (C-AL-BCD) 装有西普洛素,为骨感染提供了一种双重方法. 它们有效杀死细菌,促进骨愈合,克服当前治疗方法的局限性.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 传染性疾病 传染性疾病
背景情况:
- 慢性骨髓炎的治疗面临诸如抗生素耐药性等挑战,原因是骨质水泥珠不断释放药物.
- 需要新的策略来将有效的抗菌作用与骨再生相结合.
- 水凝涂层提供局部药物输送和有利于组织愈合的环境.
研究的目的:
- 开发和评估含有齐普罗夫洛克萨的酸含水凝涂层四酸-纳米二氧化物复合骨质水泥珠 (C-AL-BCD).
- 评估开发的珠子在治疗骨感染和再生方面的抗菌,抗生物膜,骨质生成和血管生成潜力.
主要方法:
- 使用SEM,FTIR,XRD和EDAX进行C-AL-BCD珠子的表征.
- 在体外研究:生物相容性,骨质活性 (生物矿物化,RUNX2,牙毛囊干细胞中的OPN表达) 和血管活性 (管道形成,内皮细胞中的迁移测定).
- 在体外抗菌和抗生物膜测定.
- 使用Drosophila melanogaster模型进行体内抗菌活性评估.
主要成果:
- C-AL-BCD珠子表现出良好的生物相容性,显著的抗菌和抗生物膜活性.
- 试验室研究显示,骨质生成矿化和标记物表达增强,血管生成活性改善.
- 在Drosophila melanogaster的体内研究表明,与受感染的对照组相比,C-AL-BCD治疗组的生存率更高.
结论:
- 开发的C-AL-BCD珠子代表了治疗骨感染的有前途的协同作用系统.
- 这种新型复合材料有效地将局部抗生素输送与增强的骨再生和血管化相结合.
- 在慢性骨髓炎和骨缺陷的当前治疗中,C-AL-BCD珠子提供了潜在的进步.
相关概念视频
01:24Hydration of Cement
953
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
953
01:17Soundness of Cement
578
The soundness of cement refers to the ability of cement paste to retain its volume after setting. Unsound cement can lead to expansion and structural damage due to the presence of free lime, magnesia, and calcium sulfate. Free lime hydrates very slowly, expanding and causing unsoundness, which is difficult to detect because it intercrystallizes with other compounds. Magnesia also reacts with water, forming crystals that can disrupt the cement's structure. Calcium sulfate can create...
578
01:21Portland Cement
691
Portland cement is the essential binding ingredient in concrete, made from finely ground materials including lime, iron, silica, and alumina. Lime is derived primarily from limestone, marble, marl, seashells, and clays, which also supply iron and alumina, while silica is sourced from sand, chalk, and bauxite. Contemporary manufacturing of Portland cement is a significant source of carbon dioxide emissions, prompting research into reducing its content in concrete through alternative...
691
01:15Fineness of Cement
523
The fineness of cement directly influences the rate of hydration, as the hydration begins at the surface of the cement particles. In addition to hydration, the fineness of cement is vital for various properties of concrete including workability, gypsum requirement, and long-term behavior. The fineness of cement is represented in terms of the specific surface of cement which is typically measured in square meters per kilogram, with several methods available for this determination.
Direct...
Direct...
523
01:20Strength of Cement
506
Strength tests for cement are not performed directly on neat cement paste due to difficulty in obtaining consistent, reliable specimens. Instead, cement is typically tested in the form of cement-sand mortar.
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in...
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in...
506
01:21Types of Cement I
390
Portland cement comes in several types, each with distinct properties and applications based on their chemical composition and hydration characteristics:
Type I (Ordinary Portland Cement) is widely used for general construction where special properties are not required. It has moderate sulfate resistance and heat of hydration.
Type II (Modified Cement) offers moderate resistance to sulfate attack and a lower rate of heat development compared to Type I. It is suitable for structures in...
Type I (Ordinary Portland Cement) is widely used for general construction where special properties are not required. It has moderate sulfate resistance and heat of hydration.
Type II (Modified Cement) offers moderate resistance to sulfate attack and a lower rate of heat development compared to Type I. It is suitable for structures in...
390