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Updated: Feb 9, 2026

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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细胞内的GPCR选择性影响通过cAMP / PKA级联通过细胞信号传递

Emily E Blythe1, Rita R Fagan2, Mark von Zastrow3

  • 1Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.

The Journal of biological chemistry
|February 7, 2026
PubMed
概括

内细胞分裂通过创建一个独特的cAMP代码来区分G蛋白结合受体 (GPCR) 信号传递. 这种空间时间代码依赖于GPCR内部化,通过蛋白激酶A (PKA) 激活影响基因转录.

关键词:
转录 DNA 的转录.生物传感器生物传感器细胞信号传递是细胞的信号传递.循环AMP (cAMP) 的使用.细胞内分泌症 (endocytosis) 是一种细胞内分泌症.蛋白质激酶A (PKA) 的作用.

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