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Updated: Feb 9, 2026

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一个进化保存的盐桥稳定了Rho GTPases中GTP水解的活性位点

Kendra Marcus1, Michael Schwabe1, Ryan Knihtila1

  • 1Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA.

The Journal of biological chemistry
|February 7, 2026
PubMed
概括

在Rho GTPases中保存的盐桥对于稳定活性部位和GTP水解至关重要. 在RhoA中破坏这种桥梁具有严重的影响,与H-Ras不同,突出其对癌症药物发现的重要性.

关键词:
分子动力学分子动力学分子进化分子演变.小型的GTP酶.结构生物学结构生物学在X射线晶体学研究中,

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