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Updated: Jun 18, 2026

Viral-mediated Labeling and Transplantation of Medial Ganglionic Eminence (MGE) Cells for In Vivo Studies
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Published on: April 23, 2015

异常的中间质突出 (MGE) GABAergic神经发生有助于亨廷顿病的发病

Aldrin E Molero1, Gnanapackiam S Devakanmalai1, Yagiz M Altun1

  • 1The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Neurobiology of disease
|February 7, 2026
PubMed
概括

亨廷顿症候群 亨廷顿症候群

关键词:
发展发展发展 发展发展决定命运的决定有GABA活性的神经元神经元内部的神经元内部的神经元.神经新生是神经发生的过程.Nkx211 的意思病原发生和发病.

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...