[F]AlF-NOTA-FAPI-04 PET/CT扫描可以预测接受局部晚期直肠癌新辅助化疗或放射治疗的患者的病理完整反应
Ziyuan Zhu1, Xiang Zhang1, Zhang Yun1
1Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
使用AlF-NOTA-FAPI-04的正子发射断层扫描/计算机断层扫描 (PET/CT) 可以预测局部晚期直肠癌 (LARC) 的治疗反应. 较高的基线标记物吸收表明对新辅助化学放射治疗 (nCRT) 的反应较差.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 放射化学 放射化学是指辐射化学.
背景情况:
- 局部晚期直肠癌 (LARC) 需要有效的新辅助化学放射治疗 (nCRT).
- 预测治疗反应对于优化患者管理至关重要.
- 癌症相关纤维细胞 (CAFs) 在瘤进展和治疗耐药性方面发挥作用.
研究的目的:
- 评估AlF-NOTA-FAPI-04正子发射断层扫描/计算机断层扫描 (PET/CT) 在预测LARC的nCRT后病理完整反应 (pCR) 的实用性.
- 评估基线FAPI摄入量与CAF相关生物标志物之间的相关性.
主要方法:
- 对60名接受预治疗的LARC患者的前性评估 [18F] ALF-NOTA-FAPI-04 PET/CT.
- 40名患者接受了nCRT,其中26人接受了第二次PET/CT放射后疗法.
- 使用斯皮尔曼的等级测试和后勤回归分析了PET变量 (SUVmax,SUVmean) 和CAF标记者之间的相关性.
主要成果:
- [F]AlF-NOTA-FAPI-04 PET/CT SUVmax和SUV平均值与FAP表达呈正相关.
- SUV平均值 (AUC=0.869) 和SUVmax (AUC=0.810) 预测了pCR.
- 较高的基线SUVmean是对nCRT反应不佳的独立预测因子 (OR=0.295).
结论:
- [F]AlF-NOTA-FAPI-04 PET/CT吸收反映了LARC中CAF生物标志物的表达.
- 在 [18F] 的基线SUV平均值AlF-NOTA-FAPI-04 PET/CT是对nCRT治疗反应的显著预测指标.
- 这种成像模式在LARC中显示出个性化治疗策略的前景.
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