保护弱势群体:对成人和怀孕中RSV疫苗的叙述性审查
Kristy M Shaeer1, Krystal Bullers2, Mohammed Zaed3
1University of South Florida Taneja College of Pharmacy, Department of Pharmacotherapeutics and Clinical Research, 560 Channelside Dr, Tampa, FL 33602.
Journal of the American Pharmacists Association : JAPhA
|February 7, 2026
概括
三种新的呼吸道同胞病毒 (RSV) 疫苗在成人和孕妇中显示出有效性,安全性和免疫性. 药剂师在教育患者和支持知情的RSV疫苗接种决策方面发挥着关键作用.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 最近的进展导致了三种呼吸道同胞病毒 (RSV) 疫苗的成年人使用的批准,其中一种也被授权在怀孕期间使用.
- 这些疫苗的目标是预防RSV下呼吸道疾病 (LRTD) 在脆弱的成年人群中.
研究的目的:
- 对三种新型RSV疫苗的疗效,免疫性和安全性数据进行以药剂师为中心的叙述性审查.
- 总结营销后监测结果及其对疫苗标签的影响.
- 为药剂师提供实际指导,以提高成人和孕妇群体的疫苗接种率.
主要方法:
- 在PRISMA-ScR指导下对2022年1月至2025年6月发表的研究进行叙述性审查.
- 搜索包括MEDLINE,Web of Science和Embase,并补充了监管文件和临床试验数据.
- 符合条件的研究集中在RSVPreF3 OA,RSVpreF或mRNA-1345的安全性,免疫性或成年人或孕妇的疗效上.
主要成果:
- 所有三个审查的疫苗都在预防成人RSV-LRTD方面表现出有效性,免疫性和安全性.
- 一种疫苗是FDA授权给母亲的,为婴儿提供对RSV呼吸道疾病的保护.
- 在成年人中影响疫苗选择的因素包括比较疗效,并发症和副作用概况.
结论:
- 目前的证据支持使用许可的RSV疫苗,早期的营销后数据为安全性资料提供了信息.
- 药剂师在解决RSV疫苗接种方面的差异和促进疫苗公平方面至关重要.
- 授权的RSV疫苗提供了一种减少疾病严重程度的新策略,药剂师有能力指导患者的决策.
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