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Updated: Feb 9, 2026

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在IKKβ降解过程中合成和抗癌活动的基于帕氏类的PROTACs

Zhenxi Su1, Yiwu Wu2, Yijie Su1

  • 1School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.

Bioorganic & medicinal chemistry letters
|February 7, 2026
PubMed
概括

帕特诺利德被转化为新型蛋白质溶解向嵌合体 (PROTACs),以提高疗效. 化合物8,一种新的PROTAC,有效降解IκB激酶β (IKKβ) 并抑制三阴性乳腺癌细胞的增殖.

关键词:
在 IKKβ 降解过程中降解 IKKβ.这就是 PROTACs.帕瑟诺利德是什么类型的三阴性乳腺癌是三阴性乳腺癌.

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