长期COVID患者的口腔微生物群:试点研究
Laura Pérez-Martínez1, Lourdes Romero1, Esther Palacios2
1Centro de Investigación Biomédica de La Rioja (CIBIR), Logroño, Spain.
Enfermedades infecciosas y microbiologia clinica (English ed.)
|February 7, 2026
概括
与对照组相比,持久性COVID疾病 (PCD) 患者的口腔微生物群或唾液细胞因子没有显著差异. 然而,在PCD中,酸水平升高,这表明它可能在病情中起作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- COVID-19 流行病构成了全球健康威胁.
- 持续性COVID疾病 (PCD) 涉及SARS-CoV-2感染后的长期症状.
- 微生物群在PCD病因学中的作用正在调查中.
研究的目的:
- 为了比较PCD患者和健康对照者的口腔微生物群组成.
- 在PCD中分析唾液细胞因子和短链脂肪酸 (SCFA) 度.
- 评估与PCD相关的认知和疲劳状态.
主要方法:
- 年龄和性别匹配的病例控制研究设计.
- 16S rDNA基因测序用于口腔细菌社区概况.
- 液IL-6,TNF-α和SCFA的测量;认知/疲劳评估 (MoCA,MFIS).
主要成果:
- 口腔微生物群的α/β多样性或唾液细胞因子没有显著差异.
- 经过校正后没有显著的SCFA差异;酸呈现出趋势 (p=0.02).
- 与对照组相比,PCD患者的MoCA得分较低,MFIS得分较高 (p<0.005).
结论:
- 在PCD中高酸值得进一步研究其病理生理学作用.
- PCD与认知障碍和疲劳增加有关.
- 在这项研究中,口腔微生物群和唾液标记物没有显著区分PCD与对照物.
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