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Updated: Feb 9, 2026

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter
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Published on: August 12, 2021

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一期研究评估在中度至重度COVID-19患者中的单克隆Fc-静止SARS-CoV-2抗体

Maddalena Marconato1, Christopher Hackenbruch2, Simon Jäger3

  • 1Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland; Cluster of Excellence iFIT (EXC2180) "Image-Guided and Functionally Instructed Tumor Therapies," University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.

Clinical therapeutics
|February 7, 2026
PubMed
概括

这项研究发现,COR-101,一种新型单克隆抗体 (mAb),对住院COVID-19患者是安全的. 然而,它的有效性在对抗Omicron变异方面是有限的,这强调了对抗不断演变的病毒需要适应性治疗的需要.

关键词:
抗体依赖增强剂 (ADE) 是一种抗体依赖增强剂.在 COVID-19 疫情中,在Fc-silenced mAbs中使用.单克隆抗体 (mAbs) 是一种单克隆抗体.第一个阶段的试验.这就是SARS-CoV-2病毒.

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