妊娠期免疫激活对通过表观遗传机制对突触和神经发育途径的产前和产后影响
Bohan Zhu1, Gaoshan Li1, Justin M Saunders2
1Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.
Translational psychiatry
|February 7, 2026
概括
在小鼠中,母体免疫激活 (MIA) 改变了后代大脑基因调节,增加了神经发育障碍的风险. 这些表观遗传变化从产前期持续到产后阶段,影响大脑发育和疾病易感性.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 母亲免疫激活 (MIA) 与后代的神经发育障碍有关.
- 表观遗传修饰在早期发育过程中至关重要,并可能受到环境因素的影响.
研究的目的:
- 研究MIA对成年后代大脑的长期分子影响.
- 为了区分MIA对基因调节的产前和产后影响.
主要方法:
- 使用一种由A型流感病毒诱导的MIA小鼠模型.
- 交叉培养幼以分离产前和产后暴露效应.
- 分析了在成年后代前皮层中的基因修饰 (H3K27ac,H3K4me3) 和基因表达.
主要成果:
- 发现重叠的产前和产后MIA对增强剂活性的影响,表明持续的监管变化.
- 产前MIA影响前脑发育途径;产后MIA影响了轴突发生和突触组织.
- 对于神经精神疾病的GWAS位点,MIA响应的监管元素得到了丰富.
结论:
- 通过对大脑基因调节网络的长期表观遗传重编程,MIA有助于神经发育障碍的风险.
- 研究结果强调了早期免疫挑战在塑造长期大脑功能和疾病易感性方面的关键作用.
相关概念视频
Epigenetic Regulation
33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation
3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.9K
Active versus Passive Immunity
10.9K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
10.9K
What is the Immune System?
130.8K
Overview
130.8K
Synaptic Signaling
79.8K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.8K
Synaptic Signaling
6.7K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
6.7K


