妊娠期免疫激活对通过表观遗传机制对突触和神经发育途径的产前和产后影响

Bohan Zhu1, Gaoshan Li1, Justin M Saunders2

  • 1Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, 24061, USA.

Translational psychiatry
|February 7, 2026
PubMed
概括

在小鼠中,母体免疫激活 (MIA) 改变了后代大脑基因调节,增加了神经发育障碍的风险. 这些表观遗传变化从产前期持续到产后阶段,影响大脑发育和疾病易感性.

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