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相关概念视频

Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

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The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
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Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

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Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
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Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

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Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
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Anatomy of the Heart01:27

Anatomy of the Heart

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The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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Cardiac Catheterization III: Left Heart Catheterization01:24

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Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
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Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)01:20

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

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Two NMR-active nuclei bonded to a central atom can be involved in geminal or two-bond coupling. Geminal coupling is commonly seen between diastereotopic protons in chiral molecules and unsymmetrical alkenes, among others.
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...
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In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells
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在神经心脏引导的TMS中,针对心脑合的目标特异性和可重复性.

Zi-Jian Feng1,2,3, Sandra Martin3,4, Ole Numssen5

  • 1TMS center, The Third People's Hospital of Deqing (Deqing Hospital of Hangzhou Normal University), Deqing, 313200, China.

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概括

脊侧前额叶皮层 (DLPFC) 经过横磁刺激 (TMS) 后心率变化可以表明有效的治疗目标. 特定的DLPFC位置和刺激强度非线性调制的心脑合 (HBC).

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科学领域:

  • 神经科学是一个神经科学.
  • 心脏病学 心脏病学
  • 精神病学是一个精神病学.

背景情况:

  • 脊侧前额皮质 (DLPFC) 是跨磁刺激 (TMS) 在治疗主要抑郁症中的主要点.
  • DLPFC刺激的治疗效果与其与子前带皮层的连接有关.
  • 这两个区域都在自主调节中发挥作用,这表明心率变化可能表明刺激的有效性.

研究的目的:

  • 调查刺激强度和DLPFC目标特异性对心脑合 (HBC) 的影响.
  • 探索神经心脏引导TMS的潜力,以确定抑郁症治疗的最佳刺激目标.

主要方法:

  • 在健康参与者中利用神经心脏引导的TMS.
  • 采用了通用添加模型来分析刺激强度和位置对HBC的非线性影响.
  • 通过使用类内相关系数,评估了跨会话的个体内可重复性.

主要成果:

  • 心脑合 (HBC) 通过刺激强度和DLPFC目标位置进行非线性调节.
  • 与假刺激相比,在F3横向和F3后部点观察到对HBC产生更大的影响.
  • 发现心率 (HR) 持续下降,特别是在F3侧面目标与超值刺激.

结论:

  • 通过TMS调节心脑合 (HBC),具体取决于刺激目标和强度.
  • 在DLPFC内的F3侧部位对HBC表现出特别一致的影响.
  • 研究结果支持使用HBC作为生理标记,以优化针对抑郁症的个性化TMS协议.