相关实验视频

Updated: Feb 9, 2026

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging

Published on: April 28, 2017

通过预先训练和微调的基于学习的几次射击管道发现针对Acinetobacter baumannii的抗微生物

Junjie Huang^1,2, Wentao Zhang³, Aowen Wang³

¹MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China.

Nature communications

|February 7, 2026

概括

研究人员开发了一种几次射击的学习管道,以发现新型抗微生物 (AMP) 对抗多药耐药的Acinetobacter baumannii.有效. 该方法成功识别了具有低毒性和耐药性易感性的强效AMP,提供了一个新的治疗范式.

科学领域:

微生物学微生物学
计算生物学计算生物学
药物发现药物发现药物发现

背景情况:

宝曼尼菌 (Acinetobacter baumannii) 是一种多抗药性病原体,导致难以治疗的医院感染.
对于对抗Acinetobacter baumannii.有效的新型抗微生物 (AMP) 有着至关重要的需求.
有限的培训数据在发现新的AMP方面构成了重大挑战.

研究的目的:

开发和验证一些射击学习管道,以识别针对Acinetobacter baumannii.强大的AMP.
为了克服抗微生物发现的数据稀缺性挑战.
发现具有低毒性和最小耐药性潜力的新型AMP.

主要方法:

采用了集成分类,排名和回归模块的一些射击学习管道.
模块使用有限的相似和真实数据进行了预训练和微调.
该管道扫描了六,七和八的大型图书馆.

主要成果:

该管道成功确定了针对Acinetobacter baumannii和Candida albicans的活性AMP.
发现的AMP显示出低的非标毒性和可以忽略不计的耐药性易感性.
一种新型,EME7(7),有效地治疗了小鼠中的Acinetobacter baumannii肺炎,而不会造成脏损伤.

结论:

短暂的学习管道在发现强大的AMP方面是有效的,尽管培训数据有限.
这种方法为开发针对多药耐药细菌的新疗法提供了有希望的策略.
这些发现为解决抗微生物药物发现中的数据稀缺问题提供了一个范式.

更多相关视频

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Published on: April 25, 2025

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides

The Application of Open Searching-based Approaches for the Identification of Acinetobacter baumannii O-linked Glycopeptides

Published on: November 2, 2021

相关概念视频

Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

Fineness of Cement

Fineness of Cement

The fineness of cement directly influences the rate of hydration, as the hydration begins at the surface of the cement particles. In addition to hydration, the fineness of cement is vital for various properties of concrete including workability, gypsum requirement, and long-term behavior. The fineness of cement is represented in terms of the specific surface of cement which is typically measured in square meters per kilogram, with several methods available for this determination.
Direct...

Fineness Modulus

Fineness Modulus

The fineness modulus (FM) of aggregate is a numerical index that measures the coarseness or fineness of the particles. It is calculated by adding the cumulative percentages of aggregate retained on each of a specified series of sieves and dividing the sum by 100.
Consider performing sieve analysis on sand through a set of ASTM sieves. The weight of aggregate retained in each sieve and pan placed at the bottom is recorded, as given in Column B of Table 1.
To determine the fineness modulus of...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

pre-mRNA Processing

pre-mRNA Processing

In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...