在决策任务期间,单脉冲TMS功能映射感觉运动皮质
Anna Udoratina1,2, Nikita Grigorev1, Andrey Savosenkov2
1Center for Cognition and Decision making, Institute for Cognitive Neuroscience, HSE University, Moscow, 101000, Russian Federation.
Scientific reports
|February 7, 2026
概括
单脉冲横磁刺激 (spTMS) 揭示了感觉运动皮层区域在感知决策中的独特作用. 前运动皮层刺激加速了运动准备,而初级运动和体感皮层刺激对决策过程产生了复杂的影响.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 发动机控制器的控制器
背景情况:
- 感知决策包括感官编码,决策形成和运动执行.
- 了解皮层对这些子过程的贡献对于认知功能和治疗障碍至关重要.
- 单脉冲横磁刺激 (spTMS) 与漂移扩散模型 (DDM) 结合,提供了一种研究这些特定贡献的方法.
研究的目的:
- 调查感觉运动皮层区域在感知决策子过程中的独特作用.
- 描述应用于特定皮层区域的spTMS如何影响反应时间及其基础组件.
主要方法:
- 30名健康参与者执行了一项视觉感知决策任务,以右手回应.
- 单脉冲横磁性刺激 (spTMS) 在200毫秒和800毫秒后对感觉运动皮层进行了应用.
- 使用漂移扩散模型 (DDM) 分析行为数据,以量化对非决策时间 (NDT) 和证据积累时间 (EAT) 的影响.
主要成果:
- 脊尾前运动皮层 (PMdc) 的刺激选择性地减少了非决策时间 (NDT),缩短了反应时间 (RT),并表明在运动准备中发挥了作用.
- 主要运动皮层 (M1) 和主体体感皮层 (S1) 的刺激降低了NDT,但增加了证据积累时间 (EAT),导致RT没有净变化.
- 区域特异性影响强调皮质区域在决策组件中的不同参与.
结论:
- 该研究成功地剖析了使用spTMS和DDM对感知决策子过程的独特皮层贡献.
- PMdc在运动准备 (减少NDT) 中发挥着关键作用.
- M1和S1表现出复杂的调节效应,影响了动力准备和证据积累.
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