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Updated: Feb 9, 2026

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甲状腺激素系统破坏性化学物质的发育神经毒性:使用多omics方法进行系统级探索

Naïs Clavel Rolland1, Sonia Dagnino2, Pierre-Maxence Vaysse1

  • 1Bayer Crop Science, Sophia Antipolis, France.

Archives of toxicology
|February 7, 2026
PubMed
概括

甲状腺激素系统破坏性化学物质 (THSDCs) 可以影响后代的大脑发育. 这项研究使用多组学来分析PTU和PCN的影响,发现PTU引起显著的神经毒性,而PCN显示最小的不良影响.

关键词:
用于预测毒理学的生物标志物.多领域的整合.神经发育性毒性 神经发育性毒性空间转录组学 空间转录组学在系统层面的毒理学.甲状腺激素系统破坏性化学物质 (THSDCs)

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