在长期COVID中循环的线粒体和细胞损伤标志物:与认知功能,心理痛苦和炎症的联系
Lynn Matits1,2,3, Jana Schellenberg4, Matthias Mack5,6
1Sports and Rehabilitation Medicine, Ulm University Hospital, Ulm, Germany. lynn.matits@uni-ulm.de.
Molecular psychiatry
|February 7, 2026
概括
长期COVID患者表现出较低的线粒体DNA (ccf-mtDNA) 水平,这可能表明线粒体功能障碍和炎症增加. 这可能与COVID-19 (PASC) 后急性后遗症的认知衰退和心理痛苦有关.
科学领域:
- 生物医学科学 生物医学科学
- 线粒体生物学 线粒体生物学
- 传染病研究 传染病研究
背景情况:
- 持续的线粒体功能障碍与COVID-19 (PASC) 后急性后续有关.
- 有限的数据存在于线粒体生物标志物,如长期COVID中无细胞线粒体DNA (ccf-mtDNA).
- 了解这些标志物对于PASC病原和治疗至关重要.
研究的目的:
- 研究相对ccf-mtDNA与长期COVID症状之间的关联.
- 在PASC患者中探索ccf-mtDNA,认知功能,心理痛苦和炎症之间的关系.
- 确定ccf-mtDNA是否可以作为PASC的生物标志物.
主要方法:
- 一项嵌套病例控制研究,涉及228名成年人 (128名PASC,100名恢复的对照).
- 对相对ccf-mtDNA,C反应蛋白 (CRP) 和全身免疫炎症指数 (SII) 的量化.
- 神经心理测试的主要组成部分分析 (PCA) 评估认知,记忆和痛苦.
主要成果:
- 与对照组相比,PASC患者表现出较低的认知功能,更高的心理痛苦和升高的CRP.
- 在所有参与者的相对ccf-mtDNA和CRP水平之间观察到显著的负相关性.
- 在PASC患者中,相对ccf-mtDNA显著降低,这表明线粒体质量控制受损.
结论:
- 在PASC中较低的相对ccf-mtDNA可能表明线粒体功能障碍并导致炎症.
- 相对ccf-mtDNA需要进一步研究作为PASC的潜在生物标志物.
- 线粒体健康是长期COVID恢复和症状学的关键因素.
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