通过几何深度学习快速预测左心室内心脏激活:迈向心脏重同步治疗规划的一步
Ehsan Naghavi1,2, Haifeng Wang1, Vahid Ziaei-Rad1
1Dept. of Mechanical Engineering, Michigan State University, East Lansing, MI, US.
NPJ digital medicine
|February 7, 2026
概括
新的深度学习模型预测了心力衰竭患者心脏再同步治疗 (CRT) 的最佳领先位置. 这种计算方法旨在通过确定个性化治疗的理想节奏点来改善治疗反应.
科学领域:
- 计算心脏病学计算心脏病学
- 医学成像医学成像
- 医学中的人工智能.
背景情况:
- 心脏再同步治疗 (CRT) 改善了心力衰竭患者与异步收缩的结果.
- 很大一部分CRT接收者没有最佳的反应,通常是由于精确的领先位置的挑战.
- 患者特定的解剖学变异阻碍了目前规划最佳节奏地点的方法.
研究的目的:
- 开发先进的计算模型,用于预测心脏电活化.
- 创建深度学习工具,以实时识别左心室 (LV) 中的最佳节奏位.
- 为CRT的个性化程序前规划建立一个in-silico框架.
主要方法:
- 开发了两个几何深度学习模型:图形神经网络 (GNN) 和几何信息神经运算符 (GINO).
- 在各种LV几何形状和电性质的有限元模拟的广泛数据上训练模型.
- 在合成和现实世界患者特定的LV几何形状上验证模型.
主要成果:
- 与GNN相比,GINO模型在合成LV几何上表现优越 (1.38%对2.44%的误差).
- 无论是GNN和GINO模型,在真实世界LV几何上都显示了可比的准确性 (4.07%对4.79%的误差).
- 开发了一个工作流程,以使用模型识别最佳的LV步调站点,从噪音数据中稳定地恢复参数.
结论:
- 几何深度学习模型,特别是GINO,显示出预测心脏激活和优化CRT领先位置的显著前景.
- 开发的模型和工作流可以帮助CRT个性化程序前规划.
- 这项研究为提高CRT功效的临床决策支持工具铺平了道路.
相关概念视频
Cardiac Catheterization III: Left Heart Catheterization
751
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
751
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
3.5K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.5K
Cardiac Output I:Effect of Heart Rate on Cardiac Output
2.7K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
2.7K
The Cardiac Cycle
98.5K
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
98.5K
Cardiac Cycle
13.0K
The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
13.0K
Exercise and Cardiac Output
2.0K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
2.0K


