在基底状骨中识别甲状腺激素合成的蛋白质前体,Styela clava
Jin Zhang1, Likun Yang1,2, Brice Beinsteiner3
1Fang Zongxi, Center for Marine EvoDevo, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China.
Nature communications
|February 7, 2026
概括
研究人员在虫中发现了一种甲状腺激素 (TH) 前体蛋白,揭示了它在TH合成和幼虫转化中的作用. 这一发现揭示了脊椎动物以外TH合成的进化起源.
科学领域:
- 内分泌学 在内分泌学.
- 进化生物学 进化生物学
- 海洋生物学 海洋生物学
背景情况:
- 甲状腺激素 (THs) 对动物的发育,生长和新陈代谢至关重要.
- 在脊椎动物中,TH合成的理解很好,但由于缺乏已识别的甲状腺蛋白 (TG) 正义物,因此在无脊椎动物中表征不佳.
研究的目的:
- 为了识别一个功能性甲状腺蛋白类 (TG类) 蛋白质在阿斯基迪亚 Styela clava.
- 研究这种蛋白质在TH合成和幼虫转化中的作用.
- 探索双边人TH合成的进化历史.
主要方法:
- 免疫沉质谱法用于识别类似TG的蛋白质.
- 遗传学和表达分析以表征已识别的蛋白质.
- 试验室内测试以确认荷尔蒙产生的活性.
- 在体内淘汰实验,以评估在变形中的功能作用.
- 跨类型的TG类蛋白质的结构分析.
主要成果:
- 在Styela clava.中发现了一种功能性TG类蛋白 (ScTG类).
- 类似于scTG的蛋白质在体外具有TH合成的激素基位.
- 在体内降低了类似SCTG的TH水平,并抑制了幼虫的变形.
- 在虫幼虫中发现一个卵泡状结构是TH合成和储存的地点,它含有类似SCTG的物质.
结论:
- 鉴定到的类似SCTG的蛋白质是ascidians中TH合成的功能前体.
- 内生TH合成似乎是双边人的祖先特征.
- 这项研究提供了关于脊椎动物以外TH合成的演变的见解.
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