基于队列分析的实质性高血压肠道微生物群性别差异的验证
Pan Wang1,2, Yaxuan Yao1,2, Kaixin Yan1,2
1Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
BMC microbiology
|February 7, 2026
概括
肠道微生物群的差异与高血压有关,特别是在女性身上. 对于短链脂肪酸生产至关重要的特定细菌在高血压女性中减少,这表明高血压中存在性别特异的肠道菌群变化.
科学领域:
- 微生物组研究的研究.
- 人类生理学 人类生理学
- 基于性别的健康差异.
背景情况:
- 高血压 (HTN) 呈现出性别特异性的差异.
- 肠道微生物群 (GM) 在HTN发育中起作用.
- 在高血压患者中调查肠道细菌的基于性别的异质性至关重要.
研究的目的:
- 为了验证与高血压相关的肠道菌群的性别差异.
- 为了比较男性和女性高血压患者和健康对照人群之间的肠道微生物组变化.
主要方法:
- 对来自中国队列的106个便样本进行了基因组学分析.
- 在高血压男性,女性和健康对照者之间比较肠道微生物组组成.
- 肠道菌群分布的分析和与血压的相关性.
主要成果:
- 高血压患者和对照人群之间肠道微生物群β-多样性的显著差异.
- 性别特定的变化:仅在女性中观察到显著的肠道菌群差异.
- 在女性高血压患者中,SCFA产生细菌 (Lachnospira,Faecalibacterium,Roseburia) 的丰富性减少.
- 在高血压男性中,Ruminococcus gnavus的丰富和Lactobacillus的枯竭.
- 雌性SCFA产生的植物中的异常可能与高血压器官损伤有关.
结论:
- 肠道微生物群失生症与女性高血压的相关性更为显著.
- 性是理解肠道菌群在高血压病原发生中的作用的关键因素.
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