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工程外细胞囊泡显示双特异性T细胞参与者,用于针对性治疗B细胞恶性瘤

Xiuxiu Yang1,2, Qian Xu3,4, Jue Wang3

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, 300020, China.

Experimental hematology & oncology
|February 7, 2026
PubMed
概括

一个新的双功能细胞外囊泡 (EV) 平台,BiTE EV@STA,结合了双特异性T细胞参与剂 (BiTEs) 与STING激动剂 (STA). 这种免疫疗法激活了适应性和先天性免疫力,克服了B细胞恶性瘤的抵抗力.

关键词:
在B细胞恶性瘤中.双特异性T细胞参与者.细胞外囊泡 细胞外囊泡免疫治疗是一种免疫疗法.瘤微环境是一个微环境.cGAS-STING 信号通道的信号通道

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