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Updated: Feb 9, 2026

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
08:38

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

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M2巨细胞通过MSX2结合LEF1介导的内皮-介质细胞过渡促进异型骨化

Bao Yao1,2, Hai Nie3,4, Ji Zhou3,4

  • 1Department of Orthopedics, Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital, Chengdu, 610000, Sichuan, China. jinniu2028@163.com.

Stem cell research & therapy
|February 7, 2026
PubMed
概括

通过MSX2/LEF1/Wnt通路,M2巨通过促进内皮-介质酶过渡 (EndMT) 来驱动异型骨化 (HO). 抑制这一轴为HO提供了潜在的治疗策略.

关键词:
细胞内皮 - 介质细胞过渡不同类型的骨化异型化.在LEF1中,我们可以使用LEF1在M2巨细胞中.在MSX2中,MSX2是

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