人类牛奶巨量营养素的变化和乳腺发育延迟的危险因素:一个前性队列研究
Yuan Deng1, Mei-Jun Guan1, Shao-Chuan Chen1
1University of Electronic Science and Technology of China, Chengdu, China.
概括
乳腺发育延迟,影响23.6%的中国母亲,与妊娠糖尿病和剖腹产有关. 在这些情况下,在产后48小时内观察到较低的乳糖水平.
科学领域:
- 人类哺乳期研究研究
- 母婴营养 母婴营养
- 公共卫生流行病学 流行病学
背景情况:
- 已确立的乳糖生成II延迟的风险因素存在,但对产后早期宏观营养素组成的动态影响尚不清楚.
- 可修改因素对乳腺发育时间和母乳成分之间的关系的影响需要进一步研究.
研究的目的:
- 在中国人群中验证已知乳腺发育延迟的风险因素.
- 在产后72小时内对母乳宏观营养素 (乳糖,脂肪,蛋白质) 的特定时间变化进行表征.
- 评估可修改因素,如孕期糖尿病,对早期牛奶成分的影响.
主要方法:
- 在中国对360名参与者的前性队列研究.
- 乳腺发育的开始是由产后24小时间隔的母亲的感知决定的.
- 在分娩后24,48,72小时对母乳样本进行了巨量营养素含量分析.
主要成果:
- 乳糖生成延迟发生在23.6%的参与者中,与妊娠期糖尿病,剖腹产和怀孕前BMI≥25.0 kg/m2显著相关.
- 在分娩后24小时和48小时观察到乳糖度较低的乳糖发育延迟组 (分别p < 0.001和p = 0.04).
- 孕期糖尿病与产后24小时显著降低乳糖度有关 (p = 0.002).
结论:
- 已知的乳腺发育延迟的风险因素在研究的中国人群中得到证实.
- 时间依赖的乳糖缺乏是一个关键的发现,强调需要监测早期产后牛奶中的乳糖水平.
- 建议在产后的前48小时内对乳糖度进行早期监测,特别是对于患有妊娠糖尿病等风险因素的母亲.
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