肝硬化相关的多基因风险评分预测了肝细胞癌风险在C型肝炎病毒被根除后
Yu-Sheng Lin1, Ying-Cheng Lin1,2, Yun-Yu Chen2,3,4,5
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Alimentary pharmacology & therapeutics
|February 8, 2026
概括
脂肪肝疾病 (PRS-5) 的遗传风险评分与C型肝炎病毒 (HCV) 治疗后肝癌 (HCC) 的风险更高有关. 这一发现支持在接受直接作用抗病毒药物治疗的患者中使用PRS-5进行个性化HCC监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 对肝肥胖症的遗传倾向可能会影响肝细胞癌 (HCC) 风险的C型肝炎病毒 (HCV) 根除后.
- 在直接作用抗病毒疗法 (DAA) 后,肥胖症相关遗传风险对更广泛的患者群体的影响尚不清楚.
研究的目的:
- 评估血脂多原风险评分 (PRS-5) 与发展HCC的风险之间的关联.
- 调查PRS-5在接受DAA治疗HCV的患者中的预测价值.
主要方法:
- 使用台湾精准医学倡议数据进行的回顾性队列研究.
- 进行了基因型定型,并计算了PRS-5以量化遗传风险.
- 考克斯的比例危险模型和受限立方线分析被用来评估PRS-5和事件HCC之间的关联.
主要成果:
- 与PRS-5<0.66 (8.89%) 相比,PRS-5≥0.66与HCC的5年累积发病率 (23.97%) 与PRS-5<0.66 (8.89%) 相比显著更高.
- 较高的PRS-5,较高的体重指数 (>24 kg/m2) 和较高的纤维化-4指数 (>3.25) 独立地与增加的HCC风险有关.
- 在各种患者亚组中,PRS-5显示出预测价值,包括那些纤维化得分较低且没有肝硬化的人.
结论:
- 在DAA消除HCV后,PRS-5是增加HCC风险的独立预测因子.
- 这些发现支持将PRS-5整合到治疗HCV患者的个性化HCC监测策略中.
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